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Figure 3: (a-f) A photomicrograph of the high-dose group (III) showing (a) loss of hepatic architecture and distorted congested central vein (CV) with cellular infiltration (I) and focal area of tissue loss (→) (H&E, ×400). (b) Highly disturbed irregular pattern of hepatic cords with focal areas of ghost-like hypertrophied hepatocytes (F). Other hepatocytes show vacuolation (V) (H&E, ×400). (c) Marked cytoplasmic vacuolation (V) and enlarged Kupffer cells (KF) (H&E, ×1000). (d) Infiltration of mononuclear cells (I). Bile ducts (D) showing distortion, dilatation, and proliferation (H&E, ×400). (e) Excessive collagenous fibers deposition (MT, ×400). (f) Very strong reaction in the cytoplasm of most hepatocytes with negative staining of the hepatocytes nuclei (→) (PAS, ×400). MT, Massonfs trichrome; PAS, periodic acid Schifffs reaction. |
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