Year : 2021 | Volume
: 34 | Issue : 1 | Page : 321--327
Does Beclin 1 have a role in basal cell carcinoma?
Rehab M Samaka1, Alaa H Marey2, Tarek M Rageh3, Dania N Abo Elros4
1 Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Dermatology, Venereology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of General Surgery, Faculty of Medicine, Menoufia University, Menoufia, Egypt
4 Department of Dermatology, Venereology and STDs Department, Birket Alsabae Central Hospital, Menoufia, Egypt
To evaluate the role of Beclin 1 in basal cell carcinoma (BCC).
BCC is the most common kind of skin cancer with increased incidence. Autophagy is considered an intracellular homeostatic pathway that is related to cancer and other diseases. Beclin 1 is a specific marker for autophagy.
Patients and methods
This An Ambidirectional Cohort Study was conducted on 77 cases with BCC and 20 age-matched and sex-matched apparently healthy participants. All sections were immunohistochemical stained for Beclin 1 antibody.
Significant absolute Beclin 1 cytoplasmic localization in epidermis and dermis of control group was noted, whereas in BCC, most cases showed nucleocytoplasmic Beclin 1 expression in epithelial cells and surrounding stroma (P > 0.001 for both). High Beclin 1 H score and H score category of epithelium and stroma were significantly noted in BCC in comparison with control groups (P > 0.001 for both). There were significant associations between higher Beclin 1 stromal H score and noduloulcerative clinical presentation and adenoid variant of BCC (P = 0.001 and 0.02, respectively). Moreover, there was a positive correlation between Beclin 1 stromal H score and size of BCC.
Overexpression and nuclear localization of Beclin 1 could play a tumor-promoting role in pathogenesis of BCC.
Dania N Abo Elros
Birket Alsabae, Menoufia
|How to cite this article:|
Samaka RM, Marey AH, Rageh TM, Abo Elros DN. Does Beclin 1 have a role in basal cell carcinoma?.Menoufia Med J 2021;34:321-327
|How to cite this URL:|
Samaka RM, Marey AH, Rageh TM, Abo Elros DN. Does Beclin 1 have a role in basal cell carcinoma?. Menoufia Med J [serial online] 2021 [cited 2021 Jun 21 ];34:321-327
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2021;volume=34;issue=1;spage=321;epage=327;aulast=Samaka;type=0