Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 34  |  Issue : 1  |  Page : 23--28

Interleukin 17A gene polymorphism in alopecia areata


Iman A Seleit1, Ola Ahmed B. Mohamed1, Sally M El-Hefnawy2, Samara M Azooz3 
1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Dermatology, Andrology and STDs, Ministry of Health, Giza, Egypt

Correspondence Address:
Samara M Azooz
Abas Riad Street, El Haram, Giza 12574
Egypt

Objective The aim of the current work was to investigate if interleukin 17A (IL-17A) G197A gene polymorphism confers susceptibility to alopecia areata (AA) in Egyptian patients. Background There is strong evidence for an autoimmune etiology of AA. IL-17A is a Th17 proinflammatory cytokine that has been linked to the pathogenesis of diverse autoimmune and inflammatory diseases. Patients and methods A total of 60 patients with AA were recruited, along with 40 healthy individuals who were matched for age and sex as a control group. IL-17A (G197A) gene polymorphism was investigated using restriction fragment length polymorphism PCR. Results Presence of A allele and AA genotype was significantly associated with AA cases compared with control group (P = 0.00 for both). A significant association was found between AA genotype and A allele and clinical data of the studied cases regarding disease severity, pattern of hair loss, nail changes, and course and response of disease to treatment (P = 0.00 for all). Conclusion IL-17A (G197A) gene polymorphism is associated with AA. Further large-scale studies are recommended to underscore and validate the current findings.


How to cite this article:
Seleit IA, Mohamed OA, El-Hefnawy SM, Azooz SM. Interleukin 17A gene polymorphism in alopecia areata.Menoufia Med J 2021;34:23-28


How to cite this URL:
Seleit IA, Mohamed OA, El-Hefnawy SM, Azooz SM. Interleukin 17A gene polymorphism in alopecia areata. Menoufia Med J [serial online] 2021 [cited 2021 Oct 28 ];34:23-28
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2021;volume=34;issue=1;spage=23;epage=28;aulast=Seleit;type=0