Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 34  |  Issue : 1  |  Page : 192--196

Interleukin-6 gene -572G>C polymorphism in Egyptian children with idiopathic nephrotic syndrome


Ghada M El-Mashad1, Essam Sh Khattab2, Muhammad S El-Mekkawy1, Nagwan Y Saleh1, Wafaa N Abou El Yazed3 
1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Biochemistry and Molecular Biology, Chemistry, Biochemistry Division, Faculty of Science, Al-Azhar University, Cairo, Egypt
3 Department of Pediatric, Ministry of Health, Gharbiya Governorate, Cairo, Egypt

Correspondence Address:
Wafaa N Abou El Yazed
Hassan Radwan, Tanta
Egypt

Objective To evaluate the association of -572G > C polymorphism with idiopathic nephrotic syndrome (INS) in children. Background Interleukin 6 (IL-6) gene promoter polymorphisms, including -572G > C polymorphism, have been implicated in INS. Patients and methods A total of 55 Egyptian children with INS were recruited along with 51 healthy controls. Genotyping for IL-6 gene -572G > C polymorphism was performed by PCR followed by restriction fragment length polymorphism. Results GC genotype was more prevalent among patients compared with controls [40 vs. 7.8%, odds ratio (OR)=5.5, P = 0.002], but there was no significant difference between patients and controls regarding CC genotype (9.1 vs. 2%, OR = 5, P = 0.14). Under the dominant model, the pooled GC + CC was more prevalent among patients compared with controls (OR = 5.4, P < 0.001). The distribution of C allele was significantly higher among patients compared with controls (29.1 vs. 5.9%, OR = 5.3, P < 0.001). No significant difference was found between patients and controls regarding the prevalence of any of the alleles or genotypes under codominant, recessive, or dominant models. Conclusion IL-6 gene -572G > C polymorphism confers susceptibility to INS among children, but it has no influence on the response to steroids.


How to cite this article:
El-Mashad GM, Khattab ES, El-Mekkawy MS, Saleh NY, Abou El Yazed WN. Interleukin-6 gene -572G>C polymorphism in Egyptian children with idiopathic nephrotic syndrome.Menoufia Med J 2021;34:192-196


How to cite this URL:
El-Mashad GM, Khattab ES, El-Mekkawy MS, Saleh NY, Abou El Yazed WN. Interleukin-6 gene -572G>C polymorphism in Egyptian children with idiopathic nephrotic syndrome. Menoufia Med J [serial online] 2021 [cited 2022 Aug 9 ];34:192-196
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2021;volume=34;issue=1;spage=192;epage=196;aulast=El-Mashad;type=0