Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 33  |  Issue : 4  |  Page : 1237--1245

A comparative randomized study to evaluate the effect of azithromycin 1.5% eyedrops versus moxifloxacin 0.5% eyedrops on bacterial conjunctivitis


Hesham M. F El Maraz1, Sameh S Mandour1, Soha S. F Abd-El Maksoud2 
1 Department of Ophthalmology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Ophthalmology, Ministry of Health, Zagazig, Egypt

Correspondence Address:
Soha S. F Abd-El Maksoud
BSC, Department of Ophthalmology, Ministry of Health, Zagazig, Sharqia
Egypt

Objective To evaluate the effect of azithromycin 1.5% eyedrops versus moxifloxacin 0.5% eyedrops on bacterial conjunctivitis. Background Purulent bacterial conjunctivitis affects all ages, with high frequency in newborns and children. This study evaluates the effect of azithromycin 1.5% eyedrops with moxifloxacin 0.5% eyedrops in treatment of bacterial conjunctivitis. Patients and methods A prospective comparative randomized controlled clinical trial was conducted that included 100 participants with purulent bacterial conjunctivitis at Menoufia outpatient clinic. Patients received either azithromycin 1.5% eyedrops twice daily for 7 days or moxifloxacin 0.5% eyedrops three times per day for 7 days. The primary variable was clinical cure at days 3 and 7 on the worst eye. The cure was defined as absence of purulent discharge and bulbar conjunctivitis. Results Overall, 88% of patients in the azithromycin group and 90% in the moxifloxacin group were clinically cured at D7. Clinical cure with azithromycin was not inferior to moxifloxacin at day 7, and discharge was absent in 92% of patients treated with azithromycin and 94% with moxifloxacin. Azithromycin and moxifloxacin were well tolerated. Conclusion Azithromycin 1.5% for 7 days was as effective as moxifloxacin for 7 days. Furthermore, patients on azithromycin presented clinical cure on day 3 as patients on moxifloxacin.


How to cite this article:
El Maraz HM, Mandour SS, Abd-El Maksoud SS. A comparative randomized study to evaluate the effect of azithromycin 1.5% eyedrops versus moxifloxacin 0.5% eyedrops on bacterial conjunctivitis.Menoufia Med J 2020;33:1237-1245


How to cite this URL:
El Maraz HM, Mandour SS, Abd-El Maksoud SS. A comparative randomized study to evaluate the effect of azithromycin 1.5% eyedrops versus moxifloxacin 0.5% eyedrops on bacterial conjunctivitis. Menoufia Med J [serial online] 2020 [cited 2024 Mar 29 ];33:1237-1245
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2020;volume=33;issue=4;spage=1237;epage=1245;aulast=El;type=0