ORIGINAL ARTICLE
Year : 2020 | Volume
: 33 | Issue : 3 | Page : 1021--1025
Role of β-catenin in vitiligo: a clinical and immunohistochemical study
Mohamed A Shoeib1, Azza G. A. Farag1, Dalia R Al-Sharaky2, Reem A Hassan1, Eman N El-Shafey1, Heba N. N. Shehata1 1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Al Minufya, Egypt 2 Department of Pathology, Faculty of Medicine, Menoufia University, Al Minufya, Egypt
Correspondence Address:
Heba N. N. Shehata Batanoon, Al Minufya Egypt
Objective
This study aimed at evaluating the immunohistochemical expression of β-catenin in the involved skin in vitiligo patients and to correlate its evaluated expression with the available clinicopathological parameters in those patients.
Background
Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms, cytotoxic mechanisms, an intrinsic defect of melanocytes, oxidant–antioxidant mechanisms, and neural mechanisms. The assessment of maintenance of vitiligo could be related to β-catenin expression. The treatment of vitiligo remains a challenge.
Patients and methods
Thirty-five patients with different degrees of vitiligo severity versus 20 patients of age-matched and sex-matched healthy controls were enrolled in this study. Biopsies were taken from vitiliginous lesion of patients and from healthy skin of controls.
Results
The relative expression of β-catenin protein in vitiligo patients showed nonsignificant differences between vitiligo cases and their matched controls regarding all studied parameters (P > 0.05) except for cellular localization, which was mainly cytoplasmic in vitiligo cases (25, 80.6%) versus 50% in the control group (P = 0.001).
Conclusion
β-Catenin may have an active role in the pathogenesis of vitiligo.
How to cite this article:
Shoeib MA, Farag AG, Al-Sharaky DR, Hassan RA, El-Shafey EN, Shehata HN. Role of β-catenin in vitiligo: a clinical and immunohistochemical study.Menoufia Med J 2020;33:1021-1025
|
How to cite this URL:
Shoeib MA, Farag AG, Al-Sharaky DR, Hassan RA, El-Shafey EN, Shehata HN. Role of β-catenin in vitiligo: a clinical and immunohistochemical study. Menoufia Med J [serial online] 2020 [cited 2024 Mar 28 ];33:1021-1025
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2020;volume=33;issue=3;spage=1021;epage=1025;aulast=Shoeib;type=0 |
|
|