ORIGINAL ARTICLE
Year : 2016 | Volume
: 29 | Issue : 4 | Page : 783--788
Soluble fas levels as a marker in chronic hepatitis C
Ahmed B Mahmoud1, Enas M Ghoneim2, Azza M Abd El-Aziz2, Shimaa M Lotfy Abass3
1 Department of Medical Microbiology and Immunology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 National Liver Institute, Menoufia University, Menoufia, Egypt
3 El-Bagour Hospital, Shebin Elkom, Egypt
Correspondence Address:
Shimaa M Lotfy Abass
Department of Medical Microbiology and Immunology, Faulty of Medicine, Menoufia University, El gish Street, El Bagor, Menoufia Governorate
Egypt
Objective
The aim of the study was to investigate the effect of soluble Fas (sFas) on patients with chronic hepatitis C.
Background
Programmed cell death has been observed in leukocytes among patients with chronic Hepatitis C and hepatocellular carcinoma (HCC), and now there is a strong trend to use sFas as a predictive marker for chronic hepatitis C and tumorigenesis in HCC.
Methods
Seventy patients were divided into three groups. Group I included 30 patients with chronic hepatitis C infection due to hepatitis C virus (HCV) (cirrhotic and noncirrhotic). Group II included 20 patients with HCC with HCV infection. Group III included 20 healthy individuals without hepatitis C infection or any other disease, which served as the control group. Liver function tests, complete blood count, analysis of viral markers, analysis of HCV-RNA by PCR, and evaluation of serum sFas by enzyme-linked immunosorbent assay were carried out.
Results
Serum sFas level increases in chronic hepatitis C and HCC, with positive correlation between sFas and aspartate aminotransferase, alanine aminotransferase, total bilirubin, and direct bilirubin and negative correlation between sFas and Hb level, platelet count, serum albumin, prothrombin time, and viral load (PCR). sFas at cutoff of 6581.12 could predict patients with HCV with 83.3% sensitivity and 65% specificity. sFas at cutoff of 6960.91 could predict patients with HCC with 85% sensitivity and 30% specificity. sFas at cutoff of 9125.99 could discriminate between cirrhotic and noncirrhotic HCV patients with 80.0% sensitivity and 53.3% specificity.
Conclusion
sFas can be considered a predictive marker for chronic hepatitis C and tumorigenesis in HCC.
How to cite this article:
Mahmoud AB, Ghoneim EM, Abd El-Aziz AM, Lotfy Abass SM. Soluble fas levels as a marker in chronic hepatitis C.Menoufia Med J 2016;29:783-788
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How to cite this URL:
Mahmoud AB, Ghoneim EM, Abd El-Aziz AM, Lotfy Abass SM. Soluble fas levels as a marker in chronic hepatitis C. Menoufia Med J [serial online] 2016 [cited 2023 Oct 3 ];29:783-788
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2016;volume=29;issue=4;spage=783;epage=788;aulast=Mahmoud;type=0 |
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