Year : 2016 | Volume
: 29 | Issue : 2 | Page : 337--340
Evaluation of interleukin-6 and C-reactive protein in patients with breast cancer at Menoufia University Hospitals
Gehan K El Saeed, Dalia M Hosny Abou-elela, Mona T Ahmed El-Gendy
Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
The aim of this study was to determine the serum level of interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with breast cancer and to correlate them with the staging of the disease.
Breast cancer is a disease that continues to plague women. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases, and their levels are found to correlate with the extent of the disease.
Patients and methods:
A total of 39 female patients with breast cancer were identified for the study. Serum level of IL-6 was assessed with enzyme-linked immunosorbent assay, and CRP was measured by means of immunoturbidimetry. The patients were classified into six groups on the basis of the pathological Tumor-Node-Metastasis (TNM) system. Statistical analyses of the data were then processed.
Increase in cancer invasion and staging are generally associated with increase in preoperative serum IL-6 and CRP level. IL-6 and CRP level correlate with lymph node metastasis (P > 0.001) and distant metastasis (P > 0.001). Serum IL-6 and CRP level correlate with TNM staging (P > 0.001).
The levels of IL-6 and CRP have a positive correlation with the TNM staging system of breast cancer. Hence, IL-6 and CRP could be used as parameters to assess the prognosis of breast cancer patients.
Mona T Ahmed El-Gendy
Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Gamal Abdel Nasser Street, Shebin Al-Kom, Al-Menoufia, 32511
|How to cite this article:|
El Saeed GK, Hosny Abou-elela DM, Ahmed El-Gendy MT. Evaluation of interleukin-6 and C-reactive protein in patients with breast cancer at Menoufia University Hospitals.Menoufia Med J 2016;29:337-340
|How to cite this URL:|
El Saeed GK, Hosny Abou-elela DM, Ahmed El-Gendy MT. Evaluation of interleukin-6 and C-reactive protein in patients with breast cancer at Menoufia University Hospitals. Menoufia Med J [serial online] 2016 [cited 2023 Mar 31 ];29:337-340
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2016;volume=29;issue=2;spage=337;epage=340;aulast=El;type=0