ORIGINAL ARTICLE
Year : 2015 | Volume
: 28 | Issue : 2 | Page : 571--577
Serum hepcidin level in children with chronic renal failure either on hemodialysis or on conservative therapy
Ali M El-Shafie1, Ghada M El-Mashad1, Hossam H Hegran1, Mohsen M El-Deeb2 1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt 2 Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt
Correspondence Address:
Mohsen M El-Deeb Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Gharbia 31511 Egypt
Objective
To study serum hepcidin level in children with chronic renal failure (CRF), either on hemodialysis (HD) or on conservative therapy, and its role in anemia in chronic kidney disease (CKD) patients.
Background
The role of hepcidin in the occurrence of anemia in children with CKD.
Patients and methods
Serum samples were obtained from 30 healthy individuals and from 10 patients with chronic renal diseases, and 20 patients with CRF. The levels of serum hepcidin, serum ferritin, and serum hemoglobin were determined and the correlation between them was studied.
Results
There is a significant increase in the serum hepcidin levels in group I and group II than the control group. There was significant correlation between hepcidin and serum ferritin, and there was a negative correlation between serum hepcidin and hemoglobin and serum creatinine and clearance of serum hepcidin by HD.
Conclusion
CRF showed an increase in the serum hepcidin level that increased in severity with the increasing duration of HD, C-reactive protein, ferritin serum level and hemoglobin level. Hepcidin may serve as a marker for diagnosis and monitor anemia in CKD patients either on HD therapy or on conservative therapy. Standard dose of HD clear the serum hepcidin by about 35%.
How to cite this article:
El-Shafie AM, El-Mashad GM, Hegran HH, El-Deeb MM. Serum hepcidin level in children with chronic renal failure either on hemodialysis or on conservative therapy.Menoufia Med J 2015;28:571-577
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How to cite this URL:
El-Shafie AM, El-Mashad GM, Hegran HH, El-Deeb MM. Serum hepcidin level in children with chronic renal failure either on hemodialysis or on conservative therapy. Menoufia Med J [serial online] 2015 [cited 2024 Mar 29 ];28:571-577
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2015;volume=28;issue=2;spage=571;epage=577;aulast=El-Shafie;type=0 |
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