RT - Journal
TY - JOUR
A1 - Haggag, Magda
A1 - Farag, Azza
A1 - El-Askary, Shymaa
A1 - Ahmed, Mai
T1 - Evaluation of human papillomavirus in skin tags
YR - 2021/1/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 52
OP - 55
VO - 34
IS - 1
UL - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2021;volume=34;issue=1;spage=52;epage=55;aulast=Haggag;t=5
DO - 10.4103/mmj.mmj_200_19
N2 -
Background
Skin tags (STs) are flesh-colored, pedunculated growths, with a smooth surface. The etiology of STs is still obscured. Human papillomavirus (HPV), a small DNA virus of papovavirus family, has been implicated in the causation of STs.
Objective
To detect the relationship between HPV skin infection and STs.
Patients and methods
Patients with STs (n = 80) and age-matched and sex-matched healthy controls (n = 40) were enrolled in this case–control study. From each patient, one skin biopsy was taken from STs lesions and another one from the perilesional skin (5 cm away from STs), and from each control, site-matched punch skin biopsy was taken. PCR was used to detect HPV DNA in every tested sample.
Results
HPV positivity showed a significant stepwise upregulation from normal skin (4, 10%), passing by STs perilesional (10, 12.5%) and ended by STs lesional (38, 47.5%) specimens (P < 0.001).
Conclusion
HPV has a role in the pathogenesis of STs. Therefore, using of antiviral or immunotherapy may help in STs management program.
ER -