TY - JOUR
A1 - Hashish, Fatma
A1 - Abdel-Wahed, Moshira
A1 - El-Odemi, Mahmoud
A1 - El-Naidany, Sherin
A1 - ElBatsh, Maha
T1 - Possible protective effects of quercetin on doxorubicin-induced cardiotoxicity in rats
Y1 - 2021/1/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 333
EP - 339
VL - 34
IS - 1
UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2021;volume=34;issue=1;spage=333;epage=339;aulast=Hashish
DO - 10.4103/mmj.mmj_5_20
N2 -
Objective
Our study aimed to investigate the possible protective effects of quercetin (QCT) on doxorubicin (DOX)-induced cardiotoxicity in rats.
Background
DOX is an antineoplastic drug that produces cardiotoxicity; it generates highly cytotoxic-free radicals that damage the cardiomyocytes. QCT is a plant flavonoid. QCT pretreatment reduces DOX-induced oxidative stress.
Materials and methods
Fifty-five adult rats were divided into four groups: group 1 (control) received saline (5 ml/kg) orally for 4 weeks; group 2 (DOX) received six doses of DOX intraperitoneally (2.5 mg/kg) on alternative days in the last 2 weeks; group 3 (QCT + DOX) received QCT orally (10 mg/kg once daily) for 4 weeks and DOX intraperitoneally (2.5 mg/kg) in the last 2 weeks as group 2, and group 4 (QCT) received QCT (10 mg/kg once daily) orally for 4 weeks. We measured the body weight, heart weight, and ECG parameters. Serum cardiac troponin-I (cTn-I), serum malondialdehyde (MDA), and total serum antioxidant capacity (TAC) have been estimated. In addition, histopathological changes of the rat heart were assessed.
Results
The DOX group showed significant ECG changes, significant increase in serum cTn-I (P < 0.001) and MDA (P < 0.001), significant decrease in TAC (P < 0.001), pathological picture of cardiomyopathy by hematoxylin and eosin staining, and high apoptotic index (P < 0.001) by caspase-3 stain compared with the control group. QCT pretreatment improved ECG changes, significantly decreased serum cTn-I (P < 0.001) and MDA (P < 0.001), significantly increased serum TAC (P < 0.001), and improved histopathological changes of the heart with significant lower apoptotic index (P < 0.001) compared with the DOX group.
Conclusion
QCT may be a promising cardioprotective agent against DOX-induced cardiotoxicity due to its inhibition of cardiac apoptosis and oxidative stress.
ER -