%A Seleit, Iman
%A Mohamed, Ola
%A El-Hefnawy, Sally
%A Azooz, Samara
%T Interleukin 17A gene polymorphism in alopecia areata
%9 Original Article
%D 2021
%J Menoufia Medical Journal
%R 10.4103/mmj.mmj_150_19
%P 23-28
%V 34
%N 1
%U http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2021;volume=34;issue=1;spage=23;epage=28;aulast=Seleit
%8 January 1, 2021
%X
Objective
The aim of the current work was to investigate if interleukin 17A (IL-17A) G197A gene polymorphism confers susceptibility to alopecia areata (AA) in Egyptian patients.
Background
There is strong evidence for an autoimmune etiology of AA. IL-17A is a Th17 proinflammatory cytokine that has been linked to the pathogenesis of diverse autoimmune and inflammatory diseases.
Patients and methods
A total of 60 patients with AA were recruited, along with 40 healthy individuals who were matched for age and sex as a control group. IL-17A (G197A) gene polymorphism was investigated using restriction fragment length polymorphism PCR.
Results
Presence of A allele and AA genotype was significantly associated with AA cases compared with control group (P = 0.00 for both). A significant association was found between AA genotype and A allele and clinical data of the studied cases regarding disease severity, pattern of hair loss, nail changes, and course and response of disease to treatment (P = 0.00 for all).
Conclusion
IL-17A (G197A) gene polymorphism is associated with AA. Further large-scale studies are recommended to underscore and validate the current findings.
%0 Journal Article
%I Wolters Kluwer Medknow Publications
%@ 1110-2098