TY - JOUR
A1 - El-Mashad, Ghada
A1 - Khattab, Essam
A1 - El-Mekkawy, Muhammad
A1 - Saleh, Nagwan
A1 - Abou El Yazed, Wafaa
T1 - Interleukin-6 gene -572G>C polymorphism in Egyptian children with idiopathic nephrotic syndrome
Y1 - 2021/1/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 192
EP - 196
VL - 34
IS - 1
UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2021;volume=34;issue=1;spage=192;epage=196;aulast=El-Mashad
DO - 10.4103/mmj.mmj_147_19
N2 -
Objective
To evaluate the association of -572G > C polymorphism with idiopathic nephrotic syndrome (INS) in children.
Background
Interleukin 6 (IL-6) gene promoter polymorphisms, including -572G > C polymorphism, have been implicated in INS.
Patients and methods
A total of 55 Egyptian children with INS were recruited along with 51 healthy controls. Genotyping for IL-6 gene -572G > C polymorphism was performed by PCR followed by restriction fragment length polymorphism.
Results
GC genotype was more prevalent among patients compared with controls [40 vs. 7.8%, odds ratio (OR)=5.5, P = 0.002], but there was no significant difference between patients and controls regarding CC genotype (9.1 vs. 2%, OR = 5, P = 0.14). Under the dominant model, the pooled GC + CC was more prevalent among patients compared with controls (OR = 5.4, P < 0.001). The distribution of C allele was significantly higher among patients compared with controls (29.1 vs. 5.9%, OR = 5.3, P < 0.001). No significant difference was found between patients and controls regarding the prevalence of any of the alleles or genotypes under codominant, recessive, or dominant models.
Conclusion
IL-6 gene -572G > C polymorphism confers susceptibility to INS among children, but it has no influence on the response to steroids.
ER -