RT - Journal
TY - JOUR
A1 - Sanad, Zakaria
A1 - Ellakwa, Hamed
A1 - Gomaa, Alaa
A1 - Hamza, Haitham
A1 - Elsalamony, Haitham
T1 - Effect of tranexamic acid in reducing blood loss during and after cesarean delivery
YR - 2020/10/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 1270
OP - 1275
VO - 33
IS - 4
UL - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2020;volume=33;issue=4;spage=1270;epage=1275;aulast=Sanad;t=5
DO - 10.4103/mmj.mmj_129_20
N2 -
Objective
The aim was to evaluate the effect of tranexamic acid (TA) in reducing blood loss during and after elective cesarean delivery (CS).
Background
Postpartum hemorrhage is an obstetrical emergency that can follow delivery. It is a major cause of maternal sickness and maternal death.
Patients and methods
In all, 74 full-term pregnant primigravida with singleton pregnancy aged between 20 and 35 years, scheduled for elective CS were enrolled at a prospective study. The patients were divided into two groups. Group I: patients received a bolus injection of 1 g of intravenous TA diluted in 20 ml of 5% dextrose solution slowly over 5 min at 10 min before skin incision. Oxytocin 10 units in 500 ml normal saline (9% saline) intravenous drip (8 ml/min) were administrated after fetal delivery. Group II: no TA was given; oxytocin was administered as in group I. Preoperatively, complete blood picture and coagulation profile were done.
Result
Hemoglobin and hematocrit levels decreased significantly in group II than in group I (P = 0.007; 0.005) consecutively. On comparing the two studied groups, there was a significant decrease in the amount of blood loss in group I than in group II (P = 0.001). More cases in group II than in the TA group required further ecbolic treatment during the postoperative period (P = 0.018).
Conclusion
A safe dose of TA plays an effective role in reducing blood loss during lower segment CS without causing complications.
ER -