TY - JOUR
A1 - Ashour, Fawzy
A1 - Elshafie, Maathir
A1 - Naguib, Yahya
A1 - Abdelnabi, Sameh
A1 - Ameen, Omnia
T1 - Early detection of attention deficit hyperactivity disorder and/or epilepsy by oxidative stress biomarkers
Y1 - 2016/10/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 954
EP - 960
VL - 29
IS - 4
UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2016;volume=29;issue=4;spage=954;epage=960;aulast=Ashour
DO - 10.4103/1110-2098.202497
N2 - Objectives
The objective of this study was early detection of attention deficit hyperactivity disorder (ADHD) and/or epilepsy by oxidative stress biomarkers.
Background
ADHD is a developmental disorder with an etiopathology not fully understood. According to the prevailing view, oxidative metabolism may be involved.
Patients and methods
The study sample consisted of 100 children. Children were equally divided into four groups (25 children/group): group I (control group); group II (ADHD group); group III (epilepsy group); and group IV (ADHD with epilepsy group). Each participant was subjected to a multidisciplinary clinical interview using a comprehensively devised semistructured sheet covering sociodemographics, psychiatric and pediatric history, and physical examination. Patients were diagnosed with ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th ed. criteria. Venous blood samples were collected from all groups; serum malondialdehyde and glutathione S transferase levels were assessed.
Results
The mean value of serum malondialdehyde was significantly increased in the ADHD group, epilepsy group, and ADHD with epilepsy group when compared with the corresponding mean value in the control group. The mean value of serum glutathione S transferase was significantly decreased in the ADHD group, epilepsy group, and ADHD with epilepsy group when compared with the corresponding mean value in the control group.
Conclusion
Our study points out that changes in oxidative metabolism may have a role in the pathophysiology of ADHD and epilepsy.
ER -