TY - JOUR A1 - Basha, Mohamed A1 - Azmy, Rania A1 - Farag, Mai T1 - A study on the effect of estrogen, progesterone, and their cutaneous receptors in the pathogenesis of melisma Y1 - 2016/4/1 JF - Menoufia Medical Journal JO - Menoufia Med J SP - 389 EP - 392 VL - 29 IS - 2 UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2016;volume=29;issue=2;spage=389;epage=392;aulast=Basha DO - 10.4103/1110-2098.192411 N2 - Objective: The aim of the study was to assess the efficacy of estrogen, progesterone, and their cutaneous receptors in the pathogenesis of melasma. Materials and methods: From January 2013 to June 2013, 40 female patients with melasma and 20 age-matched and sex-matched healthy individuals as the control group were included. Estrogen and progesterone were measured using IMMULITE 2000. Results: Concerning the serum estrogen and progesterone levels, the patients showed a statistically significant increase in progesterone levels with a mean value of 3.65 ± 13.11 when compared with the controls with a mean value of 3.63 ± 2.64. Conclusion: Increase in serum progesterone supports the role of pregnancy in melasma. ER -