%A El-Kafrawy, Nabil
%A Shoaib, Ahmed
%A Farahat, Mohammed
%T β-Cell plasticity
%9 Review Article
%D 2016
%J Menoufia Medical Journal
%R 10.4103/1110-2098.192413
%P 181-186
%V 29
%N 2
%U http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2016;volume=29;issue=2;spage=181;epage=186;aulast=El-Kafrawy
%8 April 1, 2016
%X Objective:
The aim of this study was to present the current trends and methodologies in the preservation of the β-cell function by targeting the β-cell mass.
Data sources:
Medical text books and also the ScienceDirect database were searched from the start date of the database and a search was performed on January 2014 with no language restrictions.
Data selection:
The selected articles are systematic reviews and experimental studies that address the β-cell plasticity and the β-cell mass and plasticity.
Data extraction:
Extraction was performed according to the quality, validity, and originality of the selected reviews and studies that fulfilled the previous criteria; in addition, the main focus was on studies that presented the latest or the most updated findings on the prevention and treatment of the β-cell failure.
Data synthesis:
Each review and study were reviewed independently without intercomparisons. The layout was selected to present a wide range of data including the most recent findings on the subject.
Recent findings:
Most recent studies concluded that the successful management of the growing epidemic of type-2 diabetes involves stopping the progressive loss of the β-cell mass and/or function before diabetes develops.
Conclusion:
The main conclusion of the studies and reviews that were presented in the current research paper is that the preservation of a functional β-cell mass is the means to prevent diabetes. β-Cell plasticity is the ability of β-cells to adjust to the body's demand for insulin. Preservation of β-cell plasticity will preserve a functional β-cell mass. Once there is a functional β-cell mass diabetes cannot develop; in addition, a proper diet alone might be able to restore a good environment for the β-cell to function properly and preserve its mass, and many new strategies and approaches are being investigated for this purpose.
%0 Journal Article
%I Wolters Kluwer Medknow Publications
%@ 1110-2098