%A Shoeib, Mohamed
%A El-Shafey, Eman
%A Sonbol, Ahmed
%A Radwan Lashin, Shimaa
%T Assessment of serum interferon-γ in psoriasis
%9 Original Article
%D 2015
%J Menoufia Medical Journal
%R 10.4103/1110-2098.163907
%P 488-493
%V 28
%N 2
%U http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2015;volume=28;issue=2;spage=488;epage=493;aulast=Shoeib
%8 April 1, 2015
%X Background
Psoriasis is a common chronic, recurrent, and immune-mediated disease of the skin and joints that follows a relapsing and remitting course. Psoriasis represents a T-cell-mediated inflammatory skin disease that includes the activation of both Th1, which produces interferon-g (IFN-γ), tumor necrosis factor-α, and interleukin-2 (IL-2), and Th17, which produces IL-17, tumor necrosis factor-α, IL-6, and IL-22.
Objective
We planned this study to determine probable associations between IFN-γ, Th1 cytokine, in the sera of psoriatic patients and the possible correlation to disease severity.
Materials and methods
We studied the level of serum IFN-γ in 40 cases of plaque psoriasis, erythrodermic, and guttatepsoriasis using PASI score for assessing the severity, and in the serum of healthy 40 controls.
Results
There was a statistically significant positive correlation between the PASI score and the level of IFN-γ in all clinical types. This can suggest that serum IFN-g is a psoriasis severity and prognostic marker.
Conclusion
Serum IFN-γ in psoriatic patients can be used as a severity and prognostic marker, and then anti-IFN-γ may eventually become a useful therapeutic approach in psoriasis.
%0 Journal Article
%I Wolters Kluwer Medknow Publications
%@ 1110-2098