TY - JOUR
A1 - Boghdadi, Ibrahim
A1 - Korah, Tarek
A1 - Abd El-Atty, Ehab
A1 - Fouad, Omar
T1 - Impact of bacterial sepsis on organ failure in patients with liver cirrhosis
Y1 - 2015/4/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 372
EP - 376
VL - 28
IS - 2
UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2015;volume=28;issue=2;spage=372;epage=376;aulast=Boghdadi
DO - 10.4103/1110-2098.163887
N2 - Objective
The aim of this study was to examine the evidence for impact of bacterial sepsis and multiple organ failure in patients with liver cirrhosis.
Data sources
A review of contemporary (1995 to present) English medical literature using the terms bacterial infection, hepatic encephalopathy, multiple organ dysfunction, and spontaneous bacterial peritonitis was conducted.
Study selection
Abstracts were reviewed independently by two authors, and relevant articles were then evaluated. Exclusion criteria included editorials, non-English language, comments, and letters.
Data extraction
Level of evidence was assigned in accordance with the Oxford Center for Evidence-based Medicine guidance (levels I-V).
Results
Thirty-seven articles met the inclusion criteria; of which, 11 were of level III, 22 of level IV, and four of level V evidence. Bacterial sepsis and multiple organ failure are common in patients with liver cirrhosis. There was level III evidence that third-generation cephalosporins are the treatment of choice for infections in patients with liver cirrhosis.
Conclusion
This review indicates that bacterial sepsis and multiple organ failure are common in patients with liver cirrhosis, supported principally by level III/IV evidence.
ER -