Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 35  |  Issue : 4  |  Page : 1810-1815

Salivary C-reactive protein, mean platelet volume, and neutrophil-lymphocyte ratio as diagnostic markers of neonatal sepsis


1 Departments of Pediatrics, Faculty of Medicine, Menoufia University, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Egypt
3 Department of Pediatrics, Ministry of Health, Qwesna General Hospital, Menoufia Government, Egypt

Correspondence Address:
Rehab H El-Arabi
Beket Elsabia, Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_208_22

Rights and Permissions

Background Till now, salivary C-reactive protein (CRP), mean platelet volume (MPV), and neutrophil-lymphocyte ratio (NLR) have not been studied as markers for diagnosis of neonatal sepsis. Objectives To assess the applicability of salivary CRP, MPV, and NLR as diagnostic markers in preterm neonates with neonatal sepsis. Patients and methods A case–control study was conducted on 184 newborns from the neonatal ICU at Menoufia University Hospital and Qwesna General Hospital from 2021 to 2022. All selected newborns were divided into group I, which included 92 neonates diagnosed as having neonatal sepsis, and group II, which included 92 apparently healthy neonates. Full history taking; thorough clinical examination; laboratory investigations such as complete blood count, leukocyte count, platelet number, NLR, platelet-lymphocyte ratio, serum CRP, salivary CRP, and blood culture; and radiological investigation such as chest radiograph and cranial ultrasound were done. Results Salivary CRP, MPV, and NLR were significantly increased in the case group than the control group. The cutoff values of MPV, NLR, and salivary CRP were 8.4, 1.87, and 8.0, respectively, with sensitivity of 82.6, 97.8, and 98.9%, respectively, and specificity of 97.8, 98.9, and 100%, respectively, for detection of neonatal sepsis. Conclusion Salivary CPR, MPV, and NLR were significantly increased in neonatal sepsis than healthy neonates. However, platelet-lymphocyte ratio was not significant in neonatal sepsis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed576    
    Printed28    
    Emailed0    
    PDF Downloaded73    
    Comments [Add]    

Recommend this journal