Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 35  |  Issue : 4  |  Page : 1721-1725

Immunohistochemical expression of discoidin domain receptor 1 in keloid scar


1 Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Plastic Surgery, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt
4 Department of Dermatology and Andrology, El Bagour Hospital, Menoufia, Egypt

Correspondence Address:
Shimaa H Abdel-Raouf
El Shahed Street, Garawan, El Bagour, Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_275_22

Rights and Permissions

Objectives To assess the role of discoidin domain receptor 1 (DDR1) in keloid scar. Background Keloid scars are formed of inert masses of collagen. Therefore, expression of collagen and DDR1 may determine the nature and extent of tissue scarring. Patients and methods This case–control study was carried out on 20 patients presented with keloid and 40 age-matched, sex-matched, and site-matched apparently normal skin from apparently healthy volunteers. Skin biopsies were sent to the Pathology Department of Faculty of Medicine, Menoufia University, for histopathological assessment and immunohistochemical staining of DDR1. Results Epidermal expression of DDR1 was positive in all keloid cases (lesional and perilesional). Its intensity was mild in all lesional biopsies and in only 20% of perilesional ones. Dermal expression was positive in all perilesional cases and in only 30% of lesional biopsies. A significant difference was found between lesional and perilesional keloid regarding DDR1 expression intensity in the epidermis and dermis (P < 0.001). A significant difference was found between lesional and perilesional keloid regarding DDR1 expression H-score in the epidermis and dermis (P < 0.001). A significant positive correlation was found between lesional epidermal and lesional dermal groups regarding keloid H-score (r = 0.552; P = 0.012). In control group, positive epidermal expression of DDR1 was found in all biopsies, with cytoplasmic localization and basal topography. Mild intensity was seen in 52.5% and moderate intensity was seen in 47.5%. The mean ± SD values of H-score were 81.50 ± 39.52. Positive dermal expression of DDR1 was found in all biopsies, with cytoplasmic localization and basal topography. Mild intensity was seen in 50% and moderate intensity was seen in 50%. The mean ± SD values of H-score were 82 ± 27.38. Conclusion DDR1 expression in keloid scar is suspected in early pathogenesis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed506    
    Printed30    
    Emailed0    
    PDF Downloaded68    
    Comments [Add]    

Recommend this journal