Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2022  |  Volume : 35  |  Issue : 4  |  Page : 1630-1634

Effect of matrix metalloproteinase-9 on angiographic criteria of coronary ectasia

Department of Cardiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Remon S Adly
Faculty of Medicine, Menoufia University, Menoufia 32511
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_233_22

Rights and Permissions

Objective The aim of this study was to evaluate the correlation between serum levels of a specific matrix metalloproteinase, matrix metalloproteinase-9 (MMP-9), and the angiographic criteria of coronary artery ectasia (CAE). Background Previously, CAE was thought to be a possible manifestation of atherosclerosis, and the relation between matrix metalloproteinase in particular MMP-9 and presence and severity of CAE was not clearly established by previous investigators. Patients and methods A retrospective study of 100 eligible patients with CAE was studied regarding their clinical presentation, angiographic criteria, and relation of the severity of CAE to serum level of MMP-9. We included assessment of major cardiovascular risk factors. Results There were high serum levels of MMP-9 (>71 ug/dl) in 45% of patients with CAE, and there was a statistically significant relation (P = 0.035) of serum levels of MMP-9 with the number of ectatic vessels (100% for three-vessel disease vs. 43.38% for single-vessel ectasia). Moreover, we found a significant relation with the type of ectasia (83.33% for type 1 vs. 40% for type 2), with P = 0.015. Conclusions There is a considerable relationship between elevated levels of MMP-9 and CAE, as well as the relationship between levels of MMP-9 and severity of the CAE.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal