| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 35
| Issue : 4 | Page : 1625-1629 |
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Metastasis-associated lung adenocarcinoma transcript 1 gene polymorphism in Egyptian patients with hepatocellular carcinoma
Nesreen G Elhelbawy1, Manal A Safan1, Mostafa G Elhelbawy2, Basma A Mostafa1, Noha R Bayomy1
1 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Hepatology, National Liver Institute, Menoufia University, Menoufia, Egypt
Correspondence Address:
Manal A Safan
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Shebin Elkom
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mmj.mmj_200_22
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Objective
To evaluate the relation between rs619586 metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) gene single nucleotide polymorphism (SNP) and hepatocellular carcinoma (HCC) risk on top of hepatitis C virus (HCV).
Background
HCC is a type of primary liver cancer. It has a multitude of etiological risk factors such as HCV. The MALAT1 is a long noncoding RNA. It affects tumor cell proliferation and migration in many types of malignancy.
Patients and methods
The study included 80 subjects: 40 patients with HCC on top of HCV and 40 healthy controls. Genotyping of MALAT1 SNP (rs619586) was performed by real-time PCR.
Results
There were no significant statistical differences regarding the genotypes or allele distribution of MALAT1 SNP (rs619586) on comparing HCC on top of HCV with controls.
Conclusion
This study found that there was no significant statistical difference regarding the genotypes or allele distribution of MALAT1 SNP (rs619586) on comparing HCC on top of HCV with controls.
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