REVIEW ARTICLE |
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Year : 2022 | Volume
: 35
| Issue : 2 | Page : 345-350 |
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A study of bone–vascular axis in health and disease
Sabry A Shoeib1, Emad M El-Shebiny1, Enas S Zahran1, Alaa A. Ali Al Sayedb2
1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt 2 Department of Internal Medicine, Shebin El-Kom Teaching Hospital, Ministry of Health, Menoufia, Egypt
Correspondence Address:
Alaa A. Ali Al Sayedb Al-Tawhid Mosque Street, Quesna, Menoufia Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/mmj.mmj_171_21
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Objectives
The aim was to study bone–vascular axis in health and disease.
Data sources
Medline databases (PubMed and MedScape) and all materials available in the internet were searched. The search was performed in September 2021.
Study selection
The initial search presented 120 articles. The number of studies that met the inclusion criteria was 21. The articles included both sexes and patients with bone–vascular disease.
Data extraction
If the studies did not fulfill the inclusion criteria, they were excluded. Data from each eligible study were independently abstracted in duplicate using a data collection form to capture information on study characteristics, interventions, and quantitative results reported for each outcome of interest.
Data synthesis
Significant data were collected. Then a structured review was performed.
Finding
In total, 21 potentially relevant publications were included; it was found that cardiovascular and bone disease are pathophysiologically interrelated.
Conclusions
Cardiovascular and bone disease are pathophysiologically interrelated, even though a full understanding of the mechanisms underlying this relationship is still lacking. A better understanding of the biological link between the two processes could lead to the development of new compounds that act on both vessels and bone. Meanwhile, it would seem reasonable to consider cardiovascular disease screening in patients with advanced bone demineralization, as well as careful monitoring for signs and symptoms of cardiovascular disease in chronic kidney disease patients.
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