| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 35
| Issue : 1 | Page : 14-19 |
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The evaluation of serum zinc level in patients with acute coronary syndrome and its correlation with cardiac enzymes
Wessam ElDin Hadad El-Shafey, Walaa Mosa, Mina Boktor, Ahmed El-Kersh
Department of Cardiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Correspondence Address:
Wessam ElDin Hadad El-Shafey
32511, Shebein El Kom, Menoufia
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mmj.mmj_332_20
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Objective
To assess serum zinc level in patients presented with acute coronary syndrome and its relation to cardiac enzymes in acute myocardial infarction (AMI).
Background
Atherosclerosis is a well-known cause of myocardial infarction owing to accumulation of lipids and fibrous elements in arteries. It was found that there are highly efficient protective mechanisms in the cell, including metal-binding proteins as antioxidants and manganese superoxide dismutase and copper–zinc superoxide dismutase as enzymes. Zinc deficiency can reduce activity of superoxide dismutase linked to atherosclerosis.
Patients and methods
Our study was carried out in cardiac care units, Menoufia University Hospital, on 100 patients who presented with acute coronary syndrome and 100 other healthy participants. Routine electric-cardiogram, ECG, and full laboratory workup were done including serum zinc level.
Results
There was a statistically significant inverse correlation between serum zinc levels and cardiac biomarkers used, that is, creatine kinase, MB fraction of creatine kinase, and troponin I (cardiac troponin T) in the studied groups, where serum zinc levels were less than 57.38 μg/dl (26%), 57.38–69.70 μg/dl (24%), 69.70–79.73 μg/dl (26%), and more than or equal to 79.73 μg/dl (24%), respectively, when divided into four quartile groups, with a remarkable increase in the AMI prevalence.
Conclusion
Serum zinc levels were significantly negatively correlated with cardiac biomarkers. The AMI prevalence rate decreased with increasing zinc quartiles.
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