ORIGINAL ARTICLE |
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Year : 2021 | Volume
: 34
| Issue : 3 | Page : 884-889 |
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Association of vascular endothelial growth factor gene polymorphism with psoriasis
Wafaa A Shehata1, Mohamad A Shoeib1, Amany S. A. Swan2, Sherin S El-Nidany3
1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt 2 Department of Dermatology, Andrology and STDs, Central Quesna Hospital, Menoufia, Egypt 3 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Correspondence Address:
Amany S. A. Swan Quesna, Menoufia Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/mmj.mmj_20_20
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Background
Psoriasis is an immune-mediated complex cutaneous disorder. In its pathologic process, there is abnormal keratinocyte differentiation and proliferation, as well as inflammation, besides abnormal vascular expansion. Vascular endothelial growth factor (VEGF) acts as a potent mediator of inflammation and angiogenesis in psoriasis.
Objective
This work aimed to study the role of VEGF gene polymorphism (rs2010963) in psoriasis vulgaris.
Patients and methods
This case–control study covered 45 patients with psoriasis vulgaris and 45 age-matched and sex-matched healthy participants as a control group, and had been checked to discover C-G transition polymorphism at position +405 of the VEGF gene by a real-time PCR.
Results
There was a significant difference between cases and controls concerning the distribution of VEGF gene polymorphism (P = 0.046), and also, there was a statistically significant difference between cases and controls concerning VEGF alleles (P = 0.036).
Conclusion
There was a significant association between the genotypes of the VEGF gene polymorphism and psoriasis vulgaris, suggesting that the VEGF gene polymorphism may have a possible active role in the etiopathogenesis of psoriasis vulgaris.
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