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ORIGINAL ARTICLE
Year : 2021  |  Volume : 34  |  Issue : 2  |  Page : 461-466

Does signal transducer and activator of transcription-3 have a role in lichen planus?


1 Department of Dermatology, Venereology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Dermatology, Venereology and STDs, Birket Alsabae Central Hospital, Menoufia, Egypt

Correspondence Address:
Sara F Sultan
Birket Al Sabae City, Menoufia Governorate, Egypt
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_319_19

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Objective The aim was to evaluate the role of signal transducer and activator of transcription 3 (STAT3) in lichen planus (LP). Background LP is a chronic mucocutaneous T-cell-mediated inflammatory disease. STAT3 is responsible for signal transmission to the nucleus from many receptors and nonreceptor-associated kinases. Materials and methods A prospective case–control study was conducted on 20 cases with LP and 20 age-matched, sex-matched, and localization-matched apparently healthy participants. All sections were immunohistochemically stained for STAT3. Results There were significant differences between the studied groups regarding STAT3 positivity in both dermis and epidermis (P = 0.043 for both), as well as STAT3 intensity of expression in epidermis and dermis (P = 0.008 and 0.001, respectively). There were significant associations between moderate and strong STAT3 expression and generalized lesions, presence of precipitating factors, presence of dermal melanophages, and presence of moderate spongiosis (P = 0.01, 0.005, 0.05, and 0.04, respectively). Conclusion Overexpression of STAT3 in LP could play a role in pathogenesis and severity of LP. Anti-STAT3 target therapy might be suggested to ameliorate LP.


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