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ORIGINAL ARTICLE
Year : 2021  |  Volume : 34  |  Issue : 1  |  Page : 23-28

Interleukin 17A gene polymorphism in alopecia areata


1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Dermatology, Andrology and STDs, Ministry of Health, Giza, Egypt

Correspondence Address:
Samara M Azooz
Abas Riad Street, El Haram, Giza 12574
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_150_19

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Objective The aim of the current work was to investigate if interleukin 17A (IL-17A) G197A gene polymorphism confers susceptibility to alopecia areata (AA) in Egyptian patients. Background There is strong evidence for an autoimmune etiology of AA. IL-17A is a Th17 proinflammatory cytokine that has been linked to the pathogenesis of diverse autoimmune and inflammatory diseases. Patients and methods A total of 60 patients with AA were recruited, along with 40 healthy individuals who were matched for age and sex as a control group. IL-17A (G197A) gene polymorphism was investigated using restriction fragment length polymorphism PCR. Results Presence of A allele and AA genotype was significantly associated with AA cases compared with control group (P = 0.00 for both). A significant association was found between AA genotype and A allele and clinical data of the studied cases regarding disease severity, pattern of hair loss, nail changes, and course and response of disease to treatment (P = 0.00 for all). Conclusion IL-17A (G197A) gene polymorphism is associated with AA. Further large-scale studies are recommended to underscore and validate the current findings.


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