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Year : 2021  |  Volume : 34  |  Issue : 1  |  Page : 192-196

Interleukin-6 gene -572G>C polymorphism in Egyptian children with idiopathic nephrotic syndrome

1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Biochemistry and Molecular Biology, Chemistry, Biochemistry Division, Faculty of Science, Al-Azhar University, Cairo, Egypt
3 Department of Pediatric, Ministry of Health, Gharbiya Governorate, Cairo, Egypt

Correspondence Address:
Wafaa N Abou El Yazed
Hassan Radwan, Tanta
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_147_19

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Objective To evaluate the association of -572G > C polymorphism with idiopathic nephrotic syndrome (INS) in children. Background Interleukin 6 (IL-6) gene promoter polymorphisms, including -572G > C polymorphism, have been implicated in INS. Patients and methods A total of 55 Egyptian children with INS were recruited along with 51 healthy controls. Genotyping for IL-6 gene -572G > C polymorphism was performed by PCR followed by restriction fragment length polymorphism. Results GC genotype was more prevalent among patients compared with controls [40 vs. 7.8%, odds ratio (OR)=5.5, P = 0.002], but there was no significant difference between patients and controls regarding CC genotype (9.1 vs. 2%, OR = 5, P = 0.14). Under the dominant model, the pooled GC + CC was more prevalent among patients compared with controls (OR = 5.4, P < 0.001). The distribution of C allele was significantly higher among patients compared with controls (29.1 vs. 5.9%, OR = 5.3, P < 0.001). No significant difference was found between patients and controls regarding the prevalence of any of the alleles or genotypes under codominant, recessive, or dominant models. Conclusion IL-6 gene -572G > C polymorphism confers susceptibility to INS among children, but it has no influence on the response to steroids.

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