Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2021  |  Volume : 34  |  Issue : 1  |  Page : 192-196

Interleukin-6 gene -572G>C polymorphism in Egyptian children with idiopathic nephrotic syndrome


1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Biochemistry and Molecular Biology, Chemistry, Biochemistry Division, Faculty of Science, Al-Azhar University, Cairo, Egypt
3 Department of Pediatric, Ministry of Health, Gharbiya Governorate, Cairo, Egypt

Correspondence Address:
Wafaa N Abou El Yazed
Hassan Radwan, Tanta
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_147_19

Rights and Permissions

Objective To evaluate the association of -572G > C polymorphism with idiopathic nephrotic syndrome (INS) in children. Background Interleukin 6 (IL-6) gene promoter polymorphisms, including -572G > C polymorphism, have been implicated in INS. Patients and methods A total of 55 Egyptian children with INS were recruited along with 51 healthy controls. Genotyping for IL-6 gene -572G > C polymorphism was performed by PCR followed by restriction fragment length polymorphism. Results GC genotype was more prevalent among patients compared with controls [40 vs. 7.8%, odds ratio (OR)=5.5, P = 0.002], but there was no significant difference between patients and controls regarding CC genotype (9.1 vs. 2%, OR = 5, P = 0.14). Under the dominant model, the pooled GC + CC was more prevalent among patients compared with controls (OR = 5.4, P < 0.001). The distribution of C allele was significantly higher among patients compared with controls (29.1 vs. 5.9%, OR = 5.3, P < 0.001). No significant difference was found between patients and controls regarding the prevalence of any of the alleles or genotypes under codominant, recessive, or dominant models. Conclusion IL-6 gene -572G > C polymorphism confers susceptibility to INS among children, but it has no influence on the response to steroids.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed202    
    Printed2    
    Emailed0    
    PDF Downloaded33    
    Comments [Add]    

Recommend this journal