| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 33
| Issue : 4 | Page : 1281-1285 |
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Oral versus topical antifungal treatment for recurrent vulvovaginal candidiasis
Mohamed kandil1, Tarek M Sayyed1, Lamiaa A. A. Omran2, Abd Elhamid E. Shaheen1
1 Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Obstetrics and Gynecology, Zawyet Aal-Naoora Hospital, Menoufia University, Menoufia, Egypt
Correspondence Address:
Lamiaa A. A. Omran
MBBCh, Al-Shohdaa, Menoufia 32841
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mmj.mmj_141_20
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Objective
To evaluate the effect of using oral versus topical antimycotic preparations in treatment of recurrent vulvovaginal candidiasis.
Background
Vaginal candidiasis is a common disease in women during their lifetime. Although several antifungal drugs are routinely used for treatment, recurrent vaginal candidiasis is a challenge for patients and gynecologists.
Patients and methods
This was a randomized control trial that included 88 cases complaining of recurrent vaginal candidiasis, with occurrence ranging from 4 to 8 episodes/year, with confirmed clinical and mycological diagnosis of vaginal candidiasis. Patients were divided into two groups by randomized number sequence: group A received oral fluconazole and group B received local clotrimazole vaginal tablets. This trial was conducted at the Department of Obstetrics and Gynecology, Zawyet Aal-Naoora Hospital, in Menoufia from March 2017 to June 2018.
Results
This study revealed a total clinical cure rate of 81% for fluconazole group and 76.1% for clotrimazole group. Total mycological cure rate was 80.5% for group A and 77.3% for group B. There was no statistically significant difference regarding clinical or mycological cure rates in all visits between the two groups. The most frequent adverse effect in group A was nausea and for group B was vaginal burning sensation.
Conclusion
Response to treatment of recurrent vulvovaginal candidiasis was similar among fluconazole and long-term use of clotrimazole vaginal tablets.
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