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Year : 2020  |  Volume : 33  |  Issue : 3  |  Page : 882-885

Association of iron deficiency anemia with simple febrile seizures: a hospital-based observational case–control study

1 Department of Pediatrics, Vikas Hospital Pvt. Ltd, New Delhi, India
2 Department of Gastroenterology, Vikas Hospital Pvt Ltd, Najafgarh, New Delhi, India
3 School of Chemistry, Jiwaji University, Gwalior, Madhya Pradesh, India

Correspondence Address:
Jehangir A Bhat
Department of Pediatrics Vikas Hospital Pvt Ltd, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_37_19

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Objectives To reveal the association of iron deficiency anemia with simple febrile seizures. Background Iron deficiency anemia has aa defined role in a variety of neurological and psychological problems in children such as stroke, behavioral, and cognitive problems. Therefore, it is hypothesized that iron deficiency anemia may have a role in febrile seizures. Patients and methods It was a hospital-based observational case–control study conducted on 320 children of age group 6–59 months. Children were divided into groups. Cases (160) who presented with simple febrile seizures and controls (160) who had fever of short duration without any type of seizure or abnormal body movement. At the time of presentation to hospital, venous blood sample for routine investigations along with complete blood count of all children included in study were sent to laboratory. All data were tabulated and analyzed with relevant statistical tests. Results Iron deficiency anemia is prevalent more (nearly > 5 times) in children who has simple febrile seizures than in normal children. Thus, evaluation for iron deficiency should be done in every child who present with simple febrile seizure. Conclusion Iron deficiency was recorded in 42 and 12.5% of cases and controls, respectively. Statistically significant association was seen between iron deficiency anemia and simple febrile seizures (P = 0.001) with odds ratio of 5.139. All hematological parameters which define iron deficiency anemia were low and statistically significant in cases as compared to controls.

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