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Year : 2020  |  Volume : 33  |  Issue : 3  |  Page : 750-754

The use of human stem cells in the treatment of experimentally induced acute kidney injury

1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Physiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Internal Medicine Department, El Obour Hospital, Kafr El Sheikh, Egypt

Correspondence Address:
Mahmoud A Sobhy
El Ryaid, Kafr El Sheikh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_346_18

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Objective The aim of this study was to evaluate the effect of stem cell therapy in sepsis-induced acute kidney injury (AKI) in rats. Background AKI is defined as an abrupt or rapid decline in renal filtration function; thus, sepsis-induced AKI remains an important challenge in critical care medicine. The science of stem cells is a field with great potential for treating injury and disease. Materials and methods A total of 30 male Swiss albino rats were used in the present study. Animals were randomly divided into three groups. Group I was the control group (10 rats). Group II was the AKI group (10 rats), where sepsis-induced AKI rat model was used. Group III was the stem cell-treated AKI group (10 rats). Rats with established AKI were injected with CD34-positive stem cells. The three studied groups were assessed for serum urea, blood urea nitrogen, serum creatinine, and cystatin C. At the end, all rats were killed, and the kidneys were excised for histopathology and immunohistochemical studies. Results Cystatin C level shows high significant difference between AKI group in comparison with both control group and stem cell-treated group (P = 0.001) whereas there is no significant difference between control group and stem cell-treated group (P = 0.944). Conclusion This study showed that AKI markers improved after treatment by stem cells in AKI-induced group.

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