Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2020  |  Volume : 33  |  Issue : 3  |  Page : 1055-1058

Matrix metalloproteinase-9 in the blood of acne patients: The possible use of matrix metalloproteinase-9 as a biomarker of acne severity

1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Sarah N Hanafy Mahmoud
Shebin El Kawm, Menoufia 32511
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_98_19

Rights and Permissions

Objectives The aim of this study was to study the blood level of matrix metalloproteinase-9 (MMP-9) in acne patients and its relation to disease severity. Background The possible use of MMP-9 as a biomarker of acne severity. Patients and methods This case–control study was conducted on 45 patients with acne vulgaris collected from the Dermatology Outpatient Clinic in Menoufia University Hospital with age ranging from 18 to 25 years. The study was done during the period from June 2018 to January 2019. Acne grading was performed according to the Global Acne Grading System. Twenty normal controls matched for age and sex were included. Detailed history and clinical exa mination were carried out to exclude patients with hyperproliferative skin disorders such as psoriasis and lichen planus, patients with bullous diseases, therapy. MMP-9 was measured by the enzyme-linked immunosorbent assay method for patients and controls and the results were statistically analyzed and tabulated. Results The level of MMP-9 recorded significant elevation when compared with normal control level. In addition, a significant difference was obtained when comparing its level among mild, moderate, and severe cases. There was also an association between its level and the number of regions with inflammatory pustules and nodules but not with scars. Conclusion MMP-9 can be used in the future as a biomarker of acne severity to choose the best treatment modalities.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded26    
    Comments [Add]    

Recommend this journal