| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 33
| Issue : 3 | Page : 1041-1044 |
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Tissue expression of endothelial selectin in patients with atopic dermatitis
Azza G. A. Farag1, Dalia R. A. Sharaky2, Eman N El-Shafey1, Sawsan S Allam3
1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
2 Department of Pathology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
3 Dermatology at Ministry of Health, Damanhour, Egypt
Correspondence Address:
Sawsan S Allam
Dermatology at Ministry of Health, Damanhour, Behera
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mmj.mmj_72_19
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Objective
To investigate the role of endothelial selectin (E-selectin) in atopic dermatitis (AD) through evaluation of the immunohistochemical expressions in lesional skin biopsies.
Background
AD is a chronic, pruritic inflammatory skin disease that occurs most frequently in children. In AD, the inflammatory cascade is initiated by the release of proinflammatory cytokines from atopic keratinocytes.
Patients and methods
A total of 50 patients with AD and 10 healthy control participants were included in this case–control study. From all participants, skin biopsies were taken, and immunohistochemical staining by E-selectin monoclonal antibodies was done.
Results
There were significant elevations in E-selectin cellular localization (P = 0.01) as well as dermal inflammatory infiltrates in AD cases than controls.
Conclusion
E-selectin participates in AD pathogenesis.
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