| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 33
| Issue : 3 | Page : 1026-1030 |
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Correlation between serum vitamin D levels and severity of vitiligo
Shawky M El-Farargy1, Naglaa M Ghanayem2, Hossam A Yasien1, Mai M Gamal3
1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Al Minufya, Egypt
2 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Al Minufya, Egypt
3 Department of Dermatology, Ministry of Health, Menoufia, Egypt, Egyp
Correspondence Address:
Mai M Gamal
Nasr City, Cairo 32717
Egyp
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mmj.mmj_29_19
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Objective
To correlate between serum vitamin D levels and severity of vitiligo.
Background
Vitiligo is an acquired depigmentary disorder that affects more than 0.5–1% of the worldwide population. Vitamin D has been implicated in the pathogenesis of various autoimmune diseases. The correlation between vitiligo and vitamin D is discussed in this study.
Patients and methods
This case–control study was conducted on 60 patients with vitiligo and 60 age-matched and sex-matched healthy individuals. All patients were recruited from the Outpatient Clinic of Dermatology and Andrology Department of Shebeen El-Kom University Hospital between 1 May 2018 and 31 August 2018. Blood samples were taken, and serum levels of vitamin D were measured by enzyme-linked immunosorbent assay technique. Serum levels of vitamin D were statistically analyzed in relation to Vitiligo Area Severity Index (VASI) score using Spearman coefficient test.
Results
The patients had higher serum vitamin D levels than the controls with highly significant difference (P < 0.001). There was no significant correlation between vitamin D and VASI score in patients (P = 0.966).
Conclusion
There was no significant correlation between vitamin D levels and VASI score. Future larger controlled studies are required to obtain a wider assessment of the relationship between vitamin D level and vitiligo disease severity.
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