Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2020  |  Volume : 33  |  Issue : 3  |  Page : 1003-1006

The role of CXCL12 chemokine in patients with alopecia areata

1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Dermatology, Andrology and STDs, Menouf General Hospital, Menoufia, Egypt

Correspondence Address:
Noha A. A. Shaheen
Menouf City, Menoufia Governorate
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_393_18

Rights and Permissions

Objective The aim was to study the role of CXCL12 in patients with alopecia areata. Background Alopecia areata is an organ-specific autoimmune disease targeting the hair follicles. It causes nonscarring hair loss. It is a lymphocyte cell-mediated inflammatory type of hair loss. Chemokines are the main components of the immune system and play fundamental roles in pathogenesis of inflammatory disorders. CXCL12 is an ELR-CXC chemokine with angiogenic effects. CXCL12 (as ELR-) is strongly chemotactic for lymphocytes and neutrophils. It is plausible that failed angiogenesis in the alopecia areata patients are involved in hair loss. As CXCL12 is an angiogenic chemokine, decreased CXCL12 levels may possibly in turn lead to decreased angiogenesis and cause hair loss in the patients. Patients and methods This case–control study was conducted on 50 participants: 25 patients with alopecia areata and 25 age-matched and sex-matched healthy controls during the period from February 2018 to August 2018. All patients were subjected to full history taking, clinical examination, and laboratory investigations. Serum CXCL12 chemokine levels were measured by using the enzyme-linked immunosorbent assay technique. Results Serum CXCL12 levels were significantly decreased in alopecia areata patients (mean: 15.55 ± 6.35) compared with healthy controls (mean: 46.94 ± 41.42) (P = 0.005). There is negative significant correlation between CXCL12 and duration of disease (r = −0.491, P = 0.013). Conclusion CXCL12 chemokine is decreased in patients with alopecia areata. There is a dependent relationship between CXCL12 serum level and AA. It can be used as a diagnostic biomarker of AA activity.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded23    
    Comments [Add]    

Recommend this journal