ORIGINAL ARTICLE |
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Year : 2020 | Volume
: 33
| Issue : 1 | Page : 89-93 |
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Effect of obesity on YKL-40 serum level to evaluate its role as an independent marker in type 2 diabetic nephropathy
Mohamed A. E. Korany1, Mohamed Z Nouh1, Thoria A Omar2, Fady W. T. Morkos3
1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt 2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt 3 Department of Internal Medicine, Ministry of Health, Tanta, Egypt
Correspondence Address:
Fady W. T. Morkos Department of Internal Medicine, Ministry of Health, Tanta Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/mmj.mmj_331_18
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Objective
The objective of this study was to evaluate the serum YKL-40 level as an independent marker in patients with type 2 diabetic nephropathy (DN).
Background
DN is a microvascular complication of type 2 diabetes mellitus. The association of YKL 40 serum level with obesity and type 2 DN has not been adequately studied.
Patients and methods
This study was conducted on 75patients with type 2 DN(25 obese with type 2 DN,25 nonobese patients with type 2 DN,and25 obese without diabetes) fromJuly 2017 to February 2018. Full history, physical examination, serum urea, serum creatinine, estimated glomerular filtration rate (eGFR), glycated hemoglobin 1c (HbA1c), serum YKL-40, urinary albumin/creatinine ratio (ACR) and abdominal ultrasonography were done.
Results
There was no significant difference among the three groups regarding sex (P = 0.527), drug taking (P = 1.0), age (P = 0.149), and serum urea (P = 0.496), whereas there was a highly significant difference among all groups regarding BMI, YKL 40 serum level, ACR, HbA1c, eGFR, and serum creatinine level (P = 0.001 for all). YKL-40 level was significantly positively correlated with BMI, creatinine level, ACR, and HbA1c and in a negative correlation with eGFR in all groups.
Conclusion
YKL-40 significantly correlates with biochemical renal parameters like ACR, creatinine, and eGFR; glycemic parameter, HbA1c; and obesity measure, BMI. Our study suggests that YKL-40 can be a marker of microvascular complications such as DN but not an independent marker owing to positive affection of obesity on its serum level.
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