ORIGINAL ARTICLE |
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Year : 2018 | Volume
: 31
| Issue : 4 | Page : 1238-1243 |
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The use of sildenafil citrate versus nifedipine in women with recurrent miscarriages: a pilot study
Said A Saleh1, Tarek M Sayed1, Nabih I Elkhouly1, May E Elaidy2
1 Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt 2 Department of Obstetrics and Gynecology, El-Bagour General Hospital, Menoufia, Egypt
Correspondence Address:
May E Elaidy Department of Obstetrics and Gynecology, El-Bagour General Hospital, Menoufia, 32821 Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/mmj.mmj_122_17
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Objective
The aim of this study was to assess the effect of sildenafil citrate versus nifedipine in improving uterine and endometrial arterial blood flow in patients suffering from recurrent unexplained pregnancy loss.
Background
Recurrent pregnancy loss is unexplained in 50% of cases. Therefore, the use of sildenafil citrate and other new drugs such as nifedipine may prevent miscarriages.
Patients and methods
The present study included a control group of 20 normal fertile women with at least one live birth, and two groups of 20 patients each with recurrent unexplained miscarriages. Participants were subjected to full history taking, clinical examination, ultrasonography, and transvaginal color Doppler test. Blood flow assessments were performed two times, before and after intervention by the same operator, to measure maximum endometrial thickness and uterine arterial blood flow parameters including systolic/diastolic blood pressure ratio, pulsatility index, and resistance index.
Results
Sildenafil citrate improves endometrial thickness and uterine artery blood flow indexes significantly compared with nifedipine.
Conclusion
Sildenafil citrate improves endometrial thickness and uterine arterial blood flow parameters including systolic/diastolic ratio, pulsatility index, and resistance index significantly compared with nifedipine.
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