ORIGINAL ARTICLE |
|
Year : 2018 | Volume
: 31
| Issue : 2 | Page : 607-612 |
|
Correlation between plasma leptin hormone in diabetic patients and the extent of coronary artery disease
Ahmed Abdelaziz Emara1, Mohamed Abdelaziz Moharam1, Ahmed E Reyad2
1 Department of Cardiology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt 2 Department of Cardiology, Damietta Cardiology Center, Dmietta, Egypt
Correspondence Address:
Ahmed E Reyad Department of Cardiology, Damietta Cardiology Center, Dmietta Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/mmj.mmj_632_16
|
|
Objective
The aim of this study was to assess the correlation between the level of plasma leptin hormone in diabetic patients with atherosclerotic coronary artery disease (CAD) and the extent of coronary artery lesion using coronary angiography.
Background
Leptin is a hormone secreted from adipose tissue and is increased in obese patients in whom there is an increased risk for atherosclerotic coronary disease which can be assessed by means of coronary angiography.
Patient and methods
A total of 50 diabetic patients with CAD were studied for the assessment of plasma leptin hormone level and its correlation with the extent of CAD by means of angiography.
Results
There was a positive correlation between the level of leptin hormone and the extent of CAD.
Conclusion
The study suggests that leptin is a significant cardiovascular risk factor for atherosclerotic CAD independent of traditional cardiovascular risk factors. Leptinemia is associated with several biochemical disorders, suggesting that leptin may be a pathogenic factor in cardiovascular disease.
|
|
|
|
[FULL TEXT] [PDF]* |
|
|
|