| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 31
| Issue : 1 | Page : 98-101 |
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The role of tranexamic acid in improving quality of pediatric tonsillectomy: a double-blinded randomized controlled study
Saad D Elzayat1, Ahmed S Elgebaly2
1 Department of Otolaryngology-Head and Neck Surgery, Kaferelsheikh University, Kafr El-Sheikh, Egypt
2 Department of Anesthesia and ICU, Tanta University, Tanta, Egypt
Correspondence Address:
Ahmed S Elgebaly
Department of Anesthesia and ICU, Faculty of Medicine, Tanta University, Tanta 31511
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mmj.mmj_377_17
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Design
This was a prospective, double-blinded, randomized controlled study.
Patients and methods
The present study included 100 patients randomized into two groups: group I included patients who did not receive tranexamic acid and group II included patients who were given tranexamic acid after induction intravenously as 15 mg/kg over 10 min.
Results
In group I, the mean number and weight of gauze used during surgery were 5.1 + 1.30 pieces and 72 ± 6.334 ml, respectively, and in group II, they were 1.9 ± 0.35 pieces and 41 ± 8.221 ml, respectively (P < 0.001). In group I, the mean amount of blood in suction bag was 200 ± 52.36 ml, whereas it was 50 ± 10.36 ml in group II (P < 0.001). The difference between both groups regarding the number of gauze, weight, and the amount of blood in suction bag was highly significant (P < 0.001).
Conclusion
The present study showed that 15 mg/kg of tranexamic acid can reduce intraoperative blood loss in a highly significant manner in children undergoing tonsillectomy and in keeping stability in hemoglobin, hematocrit levels, heart rate, mean arterial blood pressure, and respiratory rate postoperatively.
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