| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 31
| Issue : 1 | Page : 38-45 |
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Letrozole with dexamethasone versus clomiphene citrate with dexamethasone for induction of ovulation in polycystic ovary
Ayman A Shabana1, Alaa El-Deen F. Al-Halby1, Abd Hamid E. Shaheen1, Ahmed M El-Naggar2
1 Department of Obstetrics and Gynecology, Faculty of Medicine-Menoufiya University, El-Shohadaa, Egypt
2 Resident of Obstetrics and Gynecology in General El-Shohadaa Hospital, El-Shohadaa, Egypt
Correspondence Address:
Ahmed M El-Naggar
Kfar El-Sheikh Khalil, Shebin El-Kom, Menoufia Governorate
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mmj.mmj_703_16
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Objective
The objective of this study was to compare the effect of letrozole with dexamethasone (DEX) versus clomiphene citrate (CC) with DEX in ovulation induction in polycystic ovarian syndrome (PCOS).
Background
PCOS is a common endocrinologic disorder in women characterized by chronic anovulation, hyperandrogenemia, and infertility.
Patients and methods
Sixty women with PCOS were included in this study and subdivided randomly into two groups. Group I included 30 women who took letrozole 2.5 mg tablet times daily starting from day 2 to day 6 of menstrual cycle and DEX 2 mg/day orally in two divided doses starting from day 3 to day 12 of the cycle. Group II includes 30 women who took the same protocol of DEX combined with CC 50 mg two times daily starting from day 2 to day 6 of the menstrual cycle. Treatment was continued for three consecutive cycles. Main outcome measures are number and diameter of follicles, endometrial thickness, ovulation rate, and pregnancy outcome.
Results
In group I, the number of mature follicles was less than three follicles/cycle with monofollicular stimulation, whereas in group II it was more than three follicles/cycle with multifollicular stimulation. The mean diameter of follicles was 18.73 in group I and 16.23 in group II. Difference in endometrial thickness was highly statistically significant (P < 0.001), where the mean endometrial thickness was 10.60 in group I and 6.97 in group II. Ovulation was more significantly detected after using letrozole than CC – in 20 (62.5%) women in group I and 12 (37.5%) women in group II (P < 0.05). Pregnancy was achieved in 11 (68.8%) women in group I, which is significantly higher than that in group II – five (31.2%) women (P = 0.05).
Conclusion
Letrozole and DEX have more success rates in ovulation induction and pregnancy outcome than CC and DEX.
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