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Year : 2018  |  Volume : 31  |  Issue : 1  |  Page : 38-45

Letrozole withdexamethasone versus clomiphene citrate with dexamethasone for induction of ovulation in polycystic ovary

1 Department of Obstetrics and Gynecology, Faculty of Medicine-Menoufiya University, El-Shohadaa, Egypt
2 Resident of Obstetrics and Gynecology in General El-Shohadaa Hospital, El-Shohadaa, Egypt

Correspondence Address:
Ahmed M El-Naggar
Kfar El-Sheikh Khalil, Shebin El-Kom, Menoufia Governorate
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_703_16

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Objective The objective of this study was to compare the effect of letrozole with dexamethasone(DEX) versus clomiphene citrate(CC) with DEX in ovulation induction in polycystic ovarian syndrome(PCOS). Background PCOS is a common endocrinologic disorder in women characterized by chronic anovulation, hyperandrogenemia, and infertility. Patients and methods Sixty women with PCOS were included in this study and subdivided randomly into two groups. GroupI included 30 women who took letrozole 2.5mg tablet times daily starting from day 2 to day 6 of menstrual cycle and DEX2mg/day orally in two divided doses starting from day 3 to day 12 of the cycle. GroupII includes 30 women who took the same protocol of DEX combined with CC 50mg two times daily starting from day 2 to day 6 of the menstrual cycle. Treatment was continued for three consecutive cycles. Main outcome measures are number and diameter of follicles, endometrial thickness, ovulation rate, and pregnancy outcome. Results In groupI, the number of mature follicles was less than three follicles/cycle with monofollicular stimulation, whereas in groupII it was more than three follicles/cycle with multifollicular stimulation. The mean diameter of follicles was 18.73 in groupI and 16.23 in groupII. Difference in endometrial thickness was highly statistically significant(P<0.001), where the mean endometrial thickness was 10.60 in groupI and 6.97 in groupII. Ovulation was more significantly detected after using letrozole than CC–in 20(62.5%) women in groupI and 12(37.5%) women in groupII(P<0.05). Pregnancy was achieved in 11(68.8%) women in groupI, which is significantly higher than that in groupII–five(31.2%) women(P=0.05). Conclusion Letrozole and DEX have more success rates in ovulation induction and pregnancy outcome than CC and DEX.

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