Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 31  |  Issue : 1  |  Page : 339-347

Study of prognostic andpredictivefactors in locally advanced breast cancer in Egypt

Pathology Department, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt

Correspondence Address:
Asma A Elmunsori
Pathology Department, Faculty of Medicine, Menoufia University, Shebeen El-Kom
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_17_18

Rights and Permissions

Objective We aimed to evaluate the prognosis in locally advanced breast cancer(LABC), and the efficacy of neoadjuvant chemotherapy in inducing pathological response in LABC. Background Despite efforts at early detection, LABC remains a clinical challenge, as distant metastasis develops in most patients, and they will experience disease relapse and eventual death. Patients and methods To study the hematoxylin and eosin-stained slides of pretreatment and post-treatment specimens and correlate them with prognostic and predictive factors. Results LABC in Egypt showed poor prognostic factors such as a high proportion of the cases have a large tumor size(46%) and axillary lymph node(LN) metastasis(87%) and younger age at time of presentation(median=53year). These results indicate a more aggressive biology of LABC in Egypt compared with the same group in developed countries. Negative preoperative LN predicts complete response in postoperative LN. Prolonged survival wasobservedwithin the triple-negative(P=0.004) and progesterone receptor negative groups(P=0.02). The disease-free survival was shortened in positive lymphovascular invasion(P=0.04) and high histologic grade(0.03). Conclusion LABC in Egypt showed poor prognostic outcome. Triple-negative and progesterone-negative cases that received neoadjuvant therapy showed significant prolonged survival.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded149    
    Comments [Add]    

Recommend this journal