ORIGINAL ARTICLE |
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Year : 2017 | Volume
: 30
| Issue : 4 | Page : 1065-1071 |
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The value of osteopontin and matrix metalloproteinase-3 in the assessment of bone mineral density in postmenopausal women
Azza M Abdu Allah1, Shereen A El Tarhouny2, Seham A Khodeer3, Walid A Shehab-Eldin4
1 Department of Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt 2 Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt 3 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt 4 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Correspondence Address:
Seham A Khodeer Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/mmj.mmj_41_17
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Objective
The aim of this study was to assess the value of osteopontin (OPN) and matrix metalloproteinase-3 (MMP-3) in the assessment of bone mineral density (BMD) in postmenopausal women.
Background
Osteoporosis is a widespread age-related skeletal disorder characterized by bone loss that increases skeletal fragility.
Patients and methods
This study was conducted on 172 postmenopausal female individuals. OPN and MMP-3 were assayed by enzyme-linked immunosorbent assay. BMD assessment was carried out by dual-energy X-ray absorptiometry. The patients were divided into three groups according to BMD: osteopenic, osteoporotic and control groups.
Results
OPN and MMP-3 levels were significantly greater in the osteoporotic and osteopenic groups than in the control group (P < 0.001). In the osteoporotic group, negative correlations between OPN, calcium, and BMD were found as well as positive correlations between OPN and MMP-3. By using the receiver operating characteristic curve, the sensitivities of both OPN and MMP-3 were found to be equal (93%), and the specificities were 100 and 84%, respectively.
Conclusion
OPN and MMP-3 were significantly increased in postmenopausal women with osteoporosis, suggesting their role in bone turnover. The preserving of normal bone mass density is a challenge for postmenopausal women to prevent bone disabilities. Hence, further studies are recommended to use the presence of OPN and MMP-3 as a regular monitoring system – being sensitive and easy to measure – for the early detection of osteoporosis in postmenopausal women.
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