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Year : 2016  |  Volume : 29  |  Issue : 4  |  Page : 887-894

Effect of vitamin D supplementation on respiratory functions and laboratory parameters in asthmatic patients

1 Department of Physiology, Faculty of Medicine, Alazhar University, Cairo, Egypt
2 Department of Biochemistry, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt
3 Department of Physiology, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt

Correspondence Address:
Eman I Elgizawy
Gamal Abd El Naser Street, Shebin El Kom, Menoufia, 32511
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-2098.202487

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Objectives The present work was designed to investigate whether vitamin D status has a relationship with the pulmonary function test results of asthmatics and assess the impact of vitamin D on interleukin-10 (IL-10). Background The incidence of bronchial asthma and other allergic disorders has increased over the past decades in nearly all nations. Many studies have suggested the role of vitamin D deficiency in both T-helper-1 and T-helper-2 diseases. Asthma is characterized by a shift toward a Th2 cytokine-like disease, either as overexpression of Th2 or as underexpression of Th1; however, the association between vitamin D, IL-10, and asthma remains uncertain. In this study, the associations of vitamin D level and IL-10 with asthma were evaluated. Patients and methods This study was conducted on 75 adult participants, aged 18 years or above, who were divided into three groups. Group I consisted of 25 adults with bronchial asthma who were treated with a classic regimen; group II consisted of another 25 adults with bronchial asthma who were treated with a combination of classic regimen and vitamin D supplementation at a dose of 2000 IU (50 mg) for 3 months; and group III consisted of 25 adults who served as controls. All patients were assessed at the beginning of the study (groups Ia, IIa, and IIIa) and at the end of 3 months (groups Ib, IIb, and IIIb). Results There was an inverse relationship between BMI in asthmatic patients and vitamin D level. Vitamin D level had direct and significant correlations with both IL-10 (r1 = 0.206,P≤ 0.001) and predicted forced expiratory volume in 1 s (FEV1) (r2 = 0.083,P≤ 0.001). There were significant associations between vitamin D level and the number of hospitalizations or unscheduled visits (P < 0.05). Conclusion These results showed that serum 25-hydroxy vitamin D levels were deficient in asthmatics, and there was a direct and significant relationship between vitamin D levels, IL-10, and pulmonary function test outcomes in asthmatic patients.

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