| ORIGINAL ARTICLE |
|
| Year : 2016 | Volume
: 29
| Issue : 2 | Page : 396-405 |
|
|
Caspase-3 expression in lichen planus
Alaa H Maraeea1, Hala S El-Rebey2, Eman A Zaky1
1 Department of Dermatology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Correspondence Address:
Eman A Zaky
Berket El-Sabae, Menoufia, 32651
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1110-2098.192428
|
|
|
Objective:
The aim of this study was to examine keratinocyte apoptosis and caspase-3 expression in lichen planus (LP).
Background:
Caspase-3 expression level in LP lesions is considered a reliable marker of apoptosis, which is frequently found in LP, but the pathways leading to apoptosis are unknown.
Patients and methods:
A total of 25 skin biopsy specimens from LP lesions were used and 17 healthy volunteers were used as controls. Histopathological examination of hematoxylin and eosin-stained sections of LP was carried out for the evaluation of histopathological parameters. The expression of caspase-3 was examined immunohistochemically.
Results:
There were highly significant differences between caspase-3 immunostaining in epidermal keratinocytes in normal skin and the lesional area of LP (P= 0.006). No statistically significant correlation was found between caspase-3 expression in keratinocytes of LP cases and the histopathological parameters studied. No statistically significant correlation was found between caspase-3 expression in dermal lymphocytes and the histopathological parameters studied. A significant relation was found between various intensities of caspase-3 expression in dermal lymphocytes and the age of the individuals (P= 0.03), where the younger age group showed a strong intensity, whereas in older individuals, the mild expression predominated, which may indicate more severe disease with more apoptosis in early-onset LP.
Conclusion:
Caspase-3 expression in epidermal keratinocytes and dermal lymphocytes may play a role in the pathogenesis of LP. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
