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Year : 2016  |  Volume : 29  |  Issue : 2  |  Page : 389-392

A study on the effect of estrogen, progesterone, and their cutaneous receptors in the pathogenesis of melisma

Department of Physiology, Faculty of Medicine, Menoufia University, Menufia, Egypt

Correspondence Address:
Mai M Farag
Department of Dermatology, Faculty of Medicine, Mansoura University, Al Azher Street, Bani Ebaied-Mansoura Governorate, 35117
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-2098.192411

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Objective: The aim of the study was to assess the efficacy of estrogen, progesterone, and their cutaneous receptors in the pathogenesis of melasma. Materials and methods: From January 2013 to June 2013, 40 female patients with melasma and 20 age-matched and sex-matched healthy individuals as the control group were included. Estrogen and progesterone were measured using IMMULITE 2000. Results: Concerning the serum estrogen and progesterone levels, the patients showed a statistically significant increase in progesterone levels with a mean value of 3.65 ± 13.11 when compared with the controls with a mean value of 3.63 ± 2.64. Conclusion: Increase in serum progesterone supports the role of pregnancy in melasma.

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