| REVIEW ARTICLE |
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| Year : 2016 | Volume
: 29
| Issue : 2 | Page : 181-186 |
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β-Cell plasticity
Nabil A El-Kafrawy1, Ahmed A Shoaib1, Mohammed A Farahat2
1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Internal Medicine, Health Insurance Organization (HIO), Menoufia, Egypt
Correspondence Address:
Mohammed A Farahat
Shebin El-Kom, Menoufia, 32511
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1110-2098.192413
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Objective:
The aim of this study was to present the current trends and methodologies in the preservation of the β-cell function by targeting the β-cell mass.
Data sources:
Medical text books and also the ScienceDirect database were searched from the start date of the database and a search was performed on January 2014 with no language restrictions.
Data selection:
The selected articles are systematic reviews and experimental studies that address the β-cell plasticity and the β-cell mass and plasticity.
Data extraction:
Extraction was performed according to the quality, validity, and originality of the selected reviews and studies that fulfilled the previous criteria; in addition, the main focus was on studies that presented the latest or the most updated findings on the prevention and treatment of the β-cell failure.
Data synthesis:
Each review and study were reviewed independently without intercomparisons. The layout was selected to present a wide range of data including the most recent findings on the subject.
Recent findings:
Most recent studies concluded that the successful management of the growing epidemic of type-2 diabetes involves stopping the progressive loss of the β-cell mass and/or function before diabetes develops.
Conclusion:
The main conclusion of the studies and reviews that were presented in the current research paper is that the preservation of a functional β-cell mass is the means to prevent diabetes. β-Cell plasticity is the ability of β-cells to adjust to the body's demand for insulin. Preservation of β-cell plasticity will preserve a functional β-cell mass. Once there is a functional β-cell mass diabetes cannot develop; in addition, a proper diet alone might be able to restore a good environment for the β-cell to function properly and preserve its mass, and many new strategies and approaches are being investigated for this purpose. |
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