ORIGINAL ARTICLE |
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Year : 2015 | Volume
: 28
| Issue : 3 | Page : 712-717 |
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Hepatocellular carcinoma in cirrhotic and noncirrhotic liver: Clinicopathological differences
Moshira M Abd El-Wahed1, Mohamad T Badr2, El Sayed A Soliman2, Asmaa G Abdou1, Doha M Taie2
1 Department of Pathology, Faculty of Medicine, Menoufyia University, Shebin El Kom, Egypt 2 Department of Pathology, National Liver Institute, Menoufyia University, Shebin El Kom, Egypt
Correspondence Address:
Doha M Taie Department of Pathology, National Liver Institute, Menoufyia University, 32511 Shebin El Kom Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/1110-2098.165822
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Objectives
The present study aimed to explore the differences between hepatocellular carcinoma (HCC) that arise in cirrhotic and noncirrhotic liver in terms of the demographical, clinical, and pathological parameters.
Background
HCC is the sixth most common cancer worldwide. Its overall incidence has increased progressively in the last two decades. Cirrhosis from any cause remains one of the strongest known risk factors for HCC. However, HCC also occurs in noncirrhotic livers.
Materials and methods
This study investigated the demographical and clinicopathological differences between 86 cases of HCC in cirrhotic liver and 17 cases of HCC in noncirrhotic liver.
Results
The main differences between the groups studied were the predominance of men among the patients with HCC in noncirrhotic livers (P = 0.04) and the large size of the tumor mass in the same group (P = 0.04) in comparison with HCC in cirrhotic livers.
Conclusion
The present study shows that HCCs arising in cirrhotic livers do not differ considerably from those occurring without cirrhosis in most demographical, clinical, and pathological criteria. However, the large size of HCC in noncirrhotic livers could be because of its late detection. |
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