Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2015  |  Volume : 28  |  Issue : 3  |  Page : 685-692

Study of interleukin-22 in patients with liver cirrhosis in Menoufia University Hospitals, Egypt

1 Department of Microbiology and Immunology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Tropical Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Amal M Abd El-Hameed Dawoud
Toukh Dalaka Village, Tala City, Menoufia Governorate, 32613
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-2098.167892

Rights and Permissions

Objectives The aims of the study were to determine serum levels of interleukin-22 (IL-22) in patients with liver cirrhosis in Menoufia University Hospitals and to detect its relation with the degree of liver cirrhosis and determine the serum level of IL-22 in relation to morbidity of patients with advanced liver cirrhosis. Background IL-22 was recently identified as a crucial parameter of pathology in experimental liver damage. Assuming that IL-22 has hepatoprotective properties in liver diseases, IL-22 may be a relevant factor for progression of liver cirrhosis. Patients and methods The study was conducted on 40 liver cirrhotic patients and 20 age-matched and sex-matched healthy individuals. All patients were subjected to history taking, complete medical examination, and thorough laboratory and radiological investigations. Serum IL-22 levels were measured by means of the ELISA technique. Results Hepatitis C virus was the major cause of liver cirrhosis in our studied group (72.5%). The majority of patients presented with liver cirrhosis-related complications at the time of inclusion into the study. Liver cirrhotic patients had significant elevation in serum levels of IL-22 when compared with healthy people (P < 0.001). IL-22 serum levels were elevated in liver cirrhosis regardless of its etiology. IL-22 serum levels were significantly more elevated in patients with ascites, hepatorenal syndrome, spontaneous bacterial peritonitis, hepatic encephalopathy, and esophageal varices as compared with patients without these complications (P = 0.05, 0.03, 0.04, 0.004, and 0.05, respectively). IL-22 serum levels showed a statistically significant positive correlation with Model for End-stage Liver Disease score (P < 0.001) and Child-Pugh score (P = 0.006). Conclusion Serum IL-22 is significantly elevated in liver cirrhotic patients and it may be relevant for the prognosis of advanced liver cirrhosis.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded136    
    Comments [Add]    

Recommend this journal